Atorvastatin vs. simvastatin: Esemokwu, myirịta, na nke dị mma maka gị
Ogwu vs. EnyiNchịkọta ọgwụ na isi iche | Ọnọdụ mesoo | Nrụ ọrụ | Mkpuchi mkpuchi na ntule ọnụahịa | Mmetụta dị n'akụkụ | Mmekọrịta ọgwụ | Arndọ aka na ntị | Ajụjụ
Atorvastatin na simvastatin bụ ọgwụ ọgwụ statin abụọ a na-akọkarị na-emeso cholesterol dị elu. Dọkịta gị nwere ike ịkọwa otu n'ime ọgwụ ndị a ma ọ bụrụ na ị nwere ọkwa LDL (obere-lipoprotein) cholesterol, nke a makwaara dị ka cholesterol ọjọọ. Site na iweda ọkwa cholesterol, atorvastatin ma ọ bụ simvastatin nwere ike inye aka belata ohere nke nkụchi obi na ọrịa strok.
N'ikwu ya kpọmkwem, atorvastatin na simvastatin na-arụ ọrụ dị ka ndị HMG-CoA reductase. Site na igbochi enzyme HMG-CoA reductase, ndị a statins belata mmepụta nke cholesterol n'ime imeju. Ebe obere cholesterol na-ekesa n'ime ọbara, ahụ na-enwe ike iweghachi cholesterol dị oke ala ma belata ogo ọkwa cholesterol n'ozuzu.
Atorvastatin na simvastatin nwere ike ịrụ ọrụ n'ụzọ ndị yiri ya mana ha nwere ụfọdụ iche na usoro onunu ogwu, nchịkwa, na mmetụta ndị nwere ike.
Kedu ihe dị iche na atorvastatin na simvastatin?
Atorvastatin makwaara aha ya, Lipitor, nke FDA kwadoro na 1996. N'ime ihe ndị ọzọ, edepụtara ya iji belata ihe ize ndụ nke nkụchi obi ma ọ bụ ọrịa strok na ndị nwere akwara obi .
Atorvastatin (Gịnị bụ Atorvastatin?) Nwere ogologo ndụ nke 14 awa. Ọgwụ ahụ na-arụ ọrụ ozugbo ọ nabatara ya, na ọrụ ya na-ebelata lipid nwere ike ịdịru 20 ruo 30 awa mgbe ochichi. Yana rosuvastatin, ma ọ bụ Crestor, atorvastatin bụ ọgwụ siri ike karịa ndị ọzọ dị ka simvastatin na pravastatin.
Atorvastatin dị na 10 mg, 20 mg, 40 mg, na 80 mg mbadamba. Startingbọchị ịmalite ịmalite bụ 10 ma ọ bụ 20 mg otu ugboro kwa ụbọchị ọ bụ ezie na usoro ọgwụgwọ oge niile nwere ike ịdị site na 10 ruo 80 mg otu ugboro kwa ụbọchị. Enwere ike iji atorvastatin mee ihe n'oge ọ bụla n'ụbọchị.
Simvastatin (Gini bu Simvastatin?) Mara aha ya, Zocor. E jiri ya tụnyere atorvastatin, simvastatin bụ ọgwụ ochie nke emere FDA mbụ na 1991. Dị ka ndị ọzọ statins, a na-eji ya belata ihe ize ndụ nke nkụchi obi na ọrịa strok na ndị nwere ihe gbasara ọrịa obi.
Chọrọ ọnụahịa kacha mma na simvastatin?
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N'adịghị ka atorvastatin, simvastatin bụ ngwaahịa . Ihe ọ pụtara, ọ naghị arụ ọrụ ruo mgbe metabolized, ma ọ bụ hazie ya, n'ime imeju ya. Mgbe emechara ya, simvastatin na-agbanwe n'ụdị ya na-arụ ọrụ, simvastatin acid, nke nwere ọkara ndụ nke ihe dịka otu elekere abụọ.
Simvastatin dị na ike nke 5 mg, 10 mg, 20 mg, 40 mg, na 80 mg. Startingkpụrụ mmalite a tụrụ aro bụ 10 ma ọ bụ 20 mg otu ugboro kwa ụbọchị, na usoro ọgwụgwọ kwesịrị ịdị site na 5 ruo 40 mg kwa ụbọchị. A na-atụ aro ka Simvastatin were n'abalị.
| Isi ọdịiche dị n'etiti atorvastatin na simvastatin | ||
|---|---|---|
| Atorvastatin | Simvastatin | |
| Otu ogwu | HMG-CoA reductase na-emechi ihe Statin | HMG-CoA reductase na-emechi ihe Statin |
| Dị ọkwa / ọnye | Dị na ụdịdị dịnụ | Dị na ụdịdị dịnụ |
| Kedu aha aha? | Ebibi | Zocor |
| Kedu ụdị (s) ọgwụ ahụ na-abata? | Mbadamba ụrọ | Mbadamba ụrọ |
| Kedu usoro onunu ogwu? | 10 ka 80 mg otu ugboro kwa ụbọchị | 5 ruo 40 mg otu ugboro kwa ụbọchị |
| Ogologo oge ole bụ ọgwụgwọ ahụ? | Ọgwụgwọ atorvastatin dị ogologo oge iji jikwaa ọkwa cholesterol ma jigide obere ihe egwu nke nkụchi obi na ọrịa strok. | Ọgwụgwọ na simvastatin bụ ogologo oge iji jikwaa ọkwa cholesterol ma jigide obere ihe egwu nke nkụchi obi na ọrịa strok. |
| Kedu onye na-a theụ ọgwụ ahụ? | Okenye; ụmụaka na ndị nọ n'afọ iri na ụma dị afọ 10 ruo 17 nwere heterozygous familial hypercholesterolemia (HeFH) | Okenye; ụmụaka na ndị nọ n'afọ iri na ụma dị afọ 10 ruo 17 nwere heterozygous familial hypercholesterolemia (HeFH) |
Ọnọdụ ndị atorvastatin na simvastatin na-agwọ
A na-eji Atorvastatin na simvastatin maka nzube ndị yiri ya. Ha abụọ na-emeso ọkwa cholesterol dị elu (hypercholesterolemia), akwa lipid (hyperlipoproteinemia), na elu triglyceride etoju (hypertriglyceridemia). N'otu oge ahụ, statins nwere ike inye aka mee ka cholesterol HDL dị elu, ụdị ezigbo cholesterol nwere mmetụta nchekwa megide ọrịa obi.
Atorvastatin na simvastatin nwekwara ike belata ihe ize ndụ nke nkụchi obi na ọrịa strok na ndị na-esonụ:
- Ndị okenye na-enweghi ọrịa obi na-arịa ọrịa obi (CHD) nwere ọtụtụ ihe egwu
- Okenye nwere ọrịa shuga Typedị nke abụọ na-enweghị CHD, mana nwere ọtụtụ ihe egwu
- Okenye nwere ọrịa CHD a chọpụtara
Ihe egwu maka ihe gbasara obi nwere ike ịgụnye ọbara mgbali elu (ọbara mgbali elu) na ọbara shuga dị elu (ọrịa shuga).
Atorvastatin na simvastatin nwere ike belata ọkwa cholesterol na lipid na ndị nwere mkpụrụ ndụ ihe nketa mkpụrụ ndụ , dị ka homozygous familial hypercholesterolemia (HoFH). Ndị a nwere ike ịgwọ ụmụaka na ndị nọ n'afọ iri na ụma (10-17 afọ) na heterozygous familial hypercholesterolemia (HeFH).
Ngwọta nke atherosclerosis, ma ọ bụ ọdụdụ abụba na mgbidi arịa ọbara, bụ ihe ọzọ kpatara atorvastatin ma ọ bụ simvastatin nwere ike ịhazi. Site na ibelata ihe edere na mgbidi arịa ọbara, ndị a nwere ike inye aka belata mgbaàmà dịka mgbu obi (angina).
| Ọnọdụ | Atorvastatin | Simvastatin |
| Hypercholesterolemia | Eeh | Eeh |
| Hyperlipoproteinemia | Eeh | Eeh |
| Hypertriglyceridemia | Eeh | Eeh |
| Mgbu obi na mgbochi ọrịa strok | Eeh | Eeh |
| Ọrịa Atherosclerosis | Eeh | Eeh |
Atorvastatin ma ọ bụ simvastatin ọ ka dị irè?
Atorvastatin na simvastatin bụ ọgwụ ọgwụ statin dị irè. Nnyocha egosiwo na ndị na-a medicationụ ọgwụ statin ha ọ dịkarịa ala 90% nke oge nwere 45% belata ihe egwu nke ịnwụ site na nkụchi obi, ọrịa strok, ma ọ bụ ihe ọ bụla. Ke ofụri ofụri, statins dị nnọọ irè na-ebelata cholesterol etoju na ẹsụhọde omume nke nkụchi obi na ọrịa strok.
Enweghi ule siri ike isi na isi nke atorvastatin na simvastatin. Agbanyeghị, a na-ewere atorvastatin dị ka ọgwụ siri ike karịa simvastatin. Na otu nnyocha nyocha na nso nso a , atorvastatin a chọpụtara na ọ dị irè karị na iweda LDL cholesterol (LDL-C) karịa simvastatin. Ọmụmụ ihe a chịkọtara nsonaazụ sitere na 50 enweghị usoro, nnwale ahụike, ma jiri ọgwụ ndị ọzọ statin dị ka fluvastatin, pravastatin, rosuvastatin na lovastatin. Rosuvastatin nwere ikike kachasị elu maka iweda ọkwa LDL n'ọmụmụ ihe ahụ.
Na otu nyochaa nyocha , A na-enyocha ihe ọmụmụ dị iche iche dị iche iche nke 75 na-atụle ọgwụ ọgwụ. Dabere na nsonaazụ otu ọmụmụ, ọgwụ kwa ụbọchị nke atorvastatin 10 mg nwere ike ibelata LDL cholesterol site na 30% -40% ebe ụbọchị ọgwụ nke simvastatin 10 mg nwere ike ibelata LDL cholesterol site na 20% -30%. Otú ọ dị, mmetụta ahụike nke ọdịiche a nwere ike ọ gaghị abụ ihe dị mkpa.
Kpọtụrụ onye na-ahụ maka ahụike gị ka ị chọpụta ụdị ọgwụgwọ kacha mma maka gị. Irè nke statins ga-adabere na ahụike gị na akụkọ ntolite ezinụlọ, n'etiti ihe ndị ọzọ.
Ihe mkpuchi na ọnụ ahịa atorvastatin vs. simvastatin?
Atorvastatin dị ka ọgwụ na-agwọ ọrịa nke fọrọ nke nta ka ọ bụrụ Medicare na atụmatụ mkpuchi ndị ọzọ na-ekpuchi. Edere ya dị ka mkpụrụ ọgwụ kwa ụbọchị nke enwere ike ịnye na ụbọchị 30 ma ọ bụ ụbọchị 90. Onu ahia ego nke atorvastatin nwere ike rue $ 250. Agbanyeghị, ọnụahịa ahụ nwere ike iweda ya na $ 15 site na iji SingleCare atorvastatin coupon.
Simvastatin dịkwa dị ka ọgwụ ọgwụ. Dịka ihe a na-edekarị, simvastatin na-ekpuchikarị Medicare na atụmatụ mkpuchi. Ogologo ọnụahịa mkpọsa nke simvastatin dị ihe dị ka $ 470. Agbanyeghị, iji kaadị ego maka simvastatin, dịka SingleCare, ị nwere ike ịtụ anya ịkwụ ụgwọ ihe na-erughị $ 10 maka ntinye ụbọchị 30 nke mbadamba 20 mg na ụlọ ahịa ọgwụ ndị na-ekere òkè.
| Atorvastatin | Simvastatin | |
| Elezie mkpuchi? | Eeh | Eeh |
| A na-ejikarị Medicare Part D? | Eeh | Eeh |
| Ọkọlọtọ onunu ogwu | 10 mg otu ugboro kwa ụbọchị (nke 30) | 20 mg otu ugboro kwa ụbọchị (nke 30) |
| Ahụkarị Medicare copay | $ 0– $ 16 | $ 0– $ 9 |
| SingleCare na-eri | $ 15 + | $ 10 + |
Nweta kaadị ego ahịa ọgwụ
Mmetụta dị egwu nke atorvastatin vs. simvastatin?
Mmetụta kachasị emetụta nke statins, dị ka atorvastatin na simvastatin, gụnyere nsogbu nke nri dị ka afọ ọsịsa, afọ mgbu, na ọgbụgbọ. Mmetụta ndị ọzọ gụnyere dizzzz na ọzịza nke aka, ụkwụ, ma ọ bụ ụkwụ (edema). Statins nwekwara ike ịkpata mgbu akwara (myalgia) ma ọ bụ adịghị ike ahụ ike (myopathy).
Ihe ize ndụ nke mgbu ahụ mgbu na-abawanye na ọnụọgụ dị elu nke statins. Otú ọ dị, e jiri ya tụnyere atorvastatin, a na-ewere simvastatin ka ọ nwee nnukwu nsogbu nke myalgia. Fọdụ ndị mmadụ nwekwara ike inwe mkpụrụ ndụ ihe nketa predisposition na myalgia site na simvastatin. Ọ bụ ezie na statins niile nwere ihe ize ndụ nke ịkpata ahụ mgbu dị ka mmetụta dị n'akụkụ, FDA ejirila ojiji ya nke simvastatin 80 mg mbadamba n'ihi oke ihe egwu.
A pụrụ ịchọta mmetụta ndị ọzọ na-ahụkarị na tebụl dị n'okpuru.
| Atorvastatin | Simvastatin | |||
| Mmetụta dị n'akụkụ | Na ọdabara? | Ugboro | Na ọdabara? | Ugboro |
| Nkwonkwo mgbu | Eeh | 7% | Eeh | 0.1% |
| Afọ ọsịsa | Eeh | 7% | Eeh | * |
| Afọ ntachi | Ọ bụghị | - | Eeh | abụọ% |
| Afọ mgbu | Eeh | 5% | Eeh | * |
| Ọgbụgbọ | Eeh | 4% | Eeh | 6% |
| Mgbu mgbu | Eeh | 4% | Eeh | 4% |
| Urinary tract ọrịa | Eeh | 6% | Eeh | 3% |
| Nasopharyngitis | Eeh | 8% | Ọ bụghị | - |
| Dizzziness | Eeh | * | Eeh | 5% |
| Dede | Eeh | * | Eeh | 3% |
* ekwughị
Ugboro ugboro anaghị adabere na data sitere na isi isi ruo n'isi. Nke a nwere ike ọ gaghị abụ ndepụta zuru oke nke mmetụta ọjọọ nwere ike ime. Biko gaa na dọkịta gị ma ọ bụ onye nlekọta ahụike ka ị mụtakwuo.
Isi Iyi: DailyMed ( Atorvastatin ), DailyMed ( Simvastatin )
Mmekọrịta ọgwụ nke atorvastatin vs. simvastatin
Atorvastatin na simvastatin bụ isi na imeju site na CYP3A4 enzyme. Ọgwụ ndị na-egbochi, ma ọ bụ na-egbochi, enzyme a nwere ike ime ka atorvastatin dịkwuo elu ma ọ bụ simvastatin na ọbara. Mgbe ejiri ya na onye na-eme ihe ike CYP3A4 dị ka clarithromycin ma ọ bụ itraconazole, atorvastatin nwere ike ibute ihe ize ndụ nke mgbu mgbu (myalgia) ma ọ bụ adịghị ike ahụ ike (myopathy). Mkpụrụ osisi vaịn bụkwa ihe mgbochi CYP3A4 nke nwere ike ịbawanye ọkwa nke atorvastatin na simvastatin. N'aka nke ọzọ, ọgwụ ndị dịka rifampin na carbamazepine bụ ndị na-emepụta CYP3A4 nwere ike ibelata ogo nke atorvastatin na simvastatin na ahụ.
Ndị na-egbochi proteinase, dịka ritonavir na lopinavir, nwere ike ibute ogo nke statins na ahụ. Ọnọdụ statin dị elu n'ọbara nwere ike iduga n'ihe ize ndụ dị ukwuu nke mmetụta ndị na-adịghị mma, gụnyere myalgia. Ngwá ọgwụ na-egbu egbu na niacin nwekwara ike ime ka myalgia dịkwuo elu mgbe ejiri ya na atorvastatin ma ọ bụ simvastatin.
Iwere atorvastatin na ogwu ogwu nwere ike ime ka obara obara nke ogwu ogwu.
Stattụ statins na warfarin a kọrọ na-eme ka ụba nke warfarin na ihe ize ndụ nke ọbara ọgbụgba. Otú ọ dị, atorvastatin bụ enweghi ike igbochi ya na aghafarin.
| Ọgwụ | Otu ogwu | Atorvastatin | Simvastatin |
| Clarithromycin Erythromycin Itraconazole Ketoconazole Mkpụrụ osisi vaịn | Ihe mgbochi CYP3A4 | Eeh | Eeh |
| Rifampin Carbamazepine | Ndị na-emepụta CYP3A4 | Eeh | Eeh |
| Ritonavir Lopinavir Simeprevir Darunavir | Ndị na-egbochi protein | Eeh | Eeh |
| Gemfibrozil Na-emegharị ahụ | Fibrates | Eeh | Eeh |
| Niacin | Ọrịa mgbochi | Eeh | Eeh |
| Digoxin | Ọrịa glycoside | Eeh | Eeh |
| Norethindrone Ethinyl estradiol | Mgbo ogwu na-egbochi onu | Eeh | Ọ bụghị |
| Warfarin | Anticoagulant | Ọ bụghị | Eeh |
Gaa ọkachamara ahụike maka mmekọrịta mmekọrịta ọgwụ ọjọọ ndị ọzọ.
Dọ aka na ntị nke atorvastatin na simvastatin
Ma atorvastatin na simvastatin nwere ike ibute ihe ojoo na-emetụta mgbu mgbu (myalgia) ma ọ bụ adịghị ike ahụ ike (myopathy). N'okwu ndị siri ike, ndị a statins nwekwara ike ịkpata rhabdomyolysis, ma ọ bụ nkwụsị ngwa ngwa nke akwara skeletal. Raredị myopathy a na-adịghị ahụkebe, nke a na-akpọ myopathy necrotizing myopathy (IMNM) na-akọkwa na iji statin mee ihe.
Atorvastatin na simvastatin na-agbanyekarị n'ime imeju. Yabụ, iji ha eme ihe nwere ike ime ka nsogbu na imeju enzyme imeju. A ga-enyocha enzymes imeju na usoro ọgwụgwọ ọ bụla. Ndị mmadụ nwere ọrịa imeju kwesịkwara inyocha ma ọ bụ zere statins kpamkpam.
Atorvastatin na simvastatin kwesịrị izere ụmụ nwanyị dị ime na ndị nne na-elekọta nwa. Ndị a nwere ike ịnwe nsogbu nke ịmụ nwa.
Ajuju ajuju ajuju banyere atorvastatin vs. simvastatin?
Gịnị bụ atorvastatin?
Atorvastatin, nke a na-akpọkwa aha ya bụ Lipitor, bụ ọgwụ statin nke ejiri belata cholesterol ma belata ihe ize ndụ nke nkụchi obi na ọrịa strok. Dosedị usoro ọgwụgwọ nke atorvastatin dị n'etiti dị n'etiti 10 ruo 80 mg kwa ụbọchị. Atorvastatin nwere ogologo ndụ nke oge 14 ma enwere ike iwere ya n'oge ọ bụla n'ụbọchị.
Gịnị bụ simvastatin?
Simvastatin mara aha ya, Zocor. Ọ bụ ọgwụ statin nke nwere ike ibelata ogo kọlesterol, nke, n'aka nke ya, nwere ike inye aka belata ohere nke nkụchi obi na ọrịa strok. Dosedị ọgwụ nkịtị nke simvastatin dị ise ruo 40 mg kwa ụbọchị. Simvastatin nwere obere obere ndụ ma na-atụ aro ka ewere ya na mgbede.
Atorvastatin na simvastatin bụ otu ihe ahụ?
Atorvastatin na simvastatin ha abụọ so na klaasị ọgwụ a na-akpọ HMG-CoA reductase inhibitors, ma ọ bụ statins. A na-eji ha eme ihe iji belata ọkwa LDL cholesterol. Agbanyeghị, ha nwere ụfọdụ iche na ike dị na etu esi ewere ha.
Atorvastatin ka ọ bụ simvastatin ka mma?
Atorvastatin na simvastatin bụ ọgwụ ọgwụ statin dị irè iji belata cholesterol ọbara. Agbanyeghị, atorvastatin ka a na-ahụta ka ọ dị ike karịa. Atorvastatin na-adị ogologo oge na ahụ ma enwere ike ị takenụ ya n'ụtụtụ ma ọ bụ n'abalị. Simvastatin nwere nsogbu dị ukwuu nke mgbu mgbu ma ọ bụ adịghị ike karịa atorvastatin, ọkachasị na oke dị elu. Onye dọkịta na-ede akwụkwọ ga-ekpebi ihe kachasị dị irè na usoro ikpe site na ikpe.
Enwere m ike iji atorvastatin ma ọ bụ simvastatin mgbe m dị ime?
Ekwesighi iji atorvastatin na simvastatin mee ihe n'oge ime ime. Cholesterol nwere ike ịbawanye n'oge ime ime ma ọ dị mkpa iji kwado nwa ebu n'afọ na-eto eto. Ya mere, ọ nweghị uru ọ bụla ị na-ewere ọnọdụ ndị a n'oge ime ime. Ha nwekwara ike ịkpata nsogbu nwa ebu n’afọ n’oge afọ ime.
Enwere m ike iji atorvastatin ma ọ bụ simvastatin na mmanya?
Dabere na ndị ọkachamara gbasara ọrịa obi , ị alcoholụbiga ihe ọ alcoholụ alcoholụ na-aba n'anya ókè kwesịrị ekwesị ma ọ bụrụ na ị na-eji ya eme ihe. Consumption consumptionụbiga mmanya ókè na-akpata ọrịa imeju bụ ebe nsogbu nwere ike ibilite. A ga-enyocha enzymes imeju na ọgwụgwọ niile na statin.
Kedu nke statin nwere obere mmetụta dị n'akụkụ?
Statins na-adịkarị nchebe na obere mmetụta dị egwu. Dị ka American Heart Association (AHA) si kwuo, uru nke statins karịrị ihe ọghọm dị na ya nke mmetụta. Otú ọ dị, ụfọdụ statins, dị ka pravastatin na fluvastatin , nwere ike inwe obere nsogbu nke myalgia karịa simvastatin na atorvastatin. N'iji ya tụnyere statins nke e nyere na obere usoro, ọ ga-eme ka mmetụta dị elu dị elu na-akpata mmetụta ndị ọzọ. Dịka ọmụmaatụ, ọgwụ nke simvastatin nke 80 mg nwere nnukwu ihe ize ndụ nke ịkpata myalgia. N'ihi nke a, ndị FDA amachila naanị ụfọdụ ndị ọgwụ a nke simvastatin.
Kedu ihe mmetụta dị ogologo oge nke atorvastatin?
Mmetụta dị ogologo oge nke ọgwụgwọ statin nwere ike ịdị iche na-adabere na onye ahụ. Ogologo oge mmetụta dị n'akụkụ nke statins nwere ike ịgụnye mgbu akwara, mmebi imeju, ọbara shuga na-arịwanye elu, yana nsogbu ncheta. Otú ọ dị, a na-ewere ihe ize ndụ nke mmetụta dị ogologo oge dị ala dị ala mgbe edere ọgwụ na ọgwụ na-edozi ya nke ọma.
Atorvastatin ọ dị njọ maka akụrụ gị?
Agaghị edozi ọgwụ nke atorvastatin na ndị nwere nsogbu akụrụ. Na ụfọdụ ndị nwere nnukwu nsogbu akụrụ, iji atorvastatin nwere ike ịdị mkpa.
N'izugbe, atorvastatin adịghị ize ndụ maka akụrụ. Otú ọ dị, iji atorvastatin nwere ike ibute ọnụọgụ nke rhabdomyolysis, nke nwere ike ibute nnukwu ọdịda akụrụ na nnukwu ikpe. Gwa dọkịta gị ma ọ bụrụ na ị nwere nsogbu gbasara nsogbu akụrụ tupu ịmalite na ọgwụ ọgwụ.
